Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

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Abstract Background [18F]FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase.This makes [18F]FDG-PET a valuable tool in the diagnostic workup of soderhamn ottoman cover neurodegenerative diseases.The utility of [18F]FDG-PET in dementia with Lewy bodies (DLB) needs further validation by considering large samples of patients and disease comparisons and applying state-of-the-art statistical methods.Here, we aimed to provide an extensive validation of the [18F]FDG-PET metabolic signatures in supporting DLB diagnosis near the first clinical assessment, which is characterized by high diagnostic uncertainty, at the single-subject level.

Methods In this retrospective study, we included N = 72 patients with heterogeneous clinical classification at entry (mild cognitive impairment, atypical parkinsonisms, possible DLB, probable DLB, and other dementias) and an established diagnosis of DLB sukrensi.com at a later follow-up.We generated patterns of [18F]FDG-PET hypometabolism in single cases by using a validated voxel-wise analysis (p 90%.Conclusion The present validation of the diagnostic and prognostic accuracy of the disease-specific brain metabolic signature in DLB at the single-subject level argues for the consideration of [18F]FDG-PET in the early phase of the DLB diagnostic flowchart.The assessment of the [18F]FDG-PET hypometabolism pattern at entry may shorten the diagnostic time, resulting in benefits for treatment options and management of patients.